Introduction
ADHD affects both children and adults and is often associated with barriers to academic, occupational and social functioning. Although there are many traditional treatments, such as drug therapy and behavioral therapy, these are not effective for everyone and may be accompanied by side effects. Hyperbaric oxygen therapy (HBOT), as a 1 new treatment, has attracted the attention of the medical community in recent years, especially in the treatment of neurological diseases.
What is HBOT
The scientific principles of HBOT

HBOT is the 1 method to place patients in a specially designed closed chamber and provide pure oxygen above one atmosphere for treatment. In this high-pressure environment, the lungs are able to inhale more oxygen than at normal pressure. This extra oxygen is dissolved in the blood and is transported with the blood circulation throughout the body, including those tissues and organs whose blood flow is impaired or deprived of oxygen. This increased oxygen supply helps promote angiogenesis, reduce inflammation, promote tissue repair, improve metabolism, and may even stimulate the growth of stem cells and nerve cells.
Medical applications of HBOT
HBOT already has a range of recognized indications in the medical field. For example, HBOT has shown significant efficacy in treating decompression sickness (a common problem encountered by divers), carbon monoxide poisoning, serious infections (such as gas gangrene), difficult-to-heal wounds (such as diabetic foot ulcers), and radiation injuries. These applications are based on its core principle-to provide sufficient oxygen to support the body’s self-healing process.
Adhd Overview
External manifestations:
The external manifestations of ADHD mainly include inattention, hyperactivity and impulsivity. Patients may have difficulty concentrating on a task for long periods of time and are easily distracted; fidget and have trouble keeping quiet; or respond without much thought. These symptoms are different in different individuals and different age stages, but they significantly affect the learning, work and social function of patients.

Pathophysiology:
With regard to the pathophysiology of ADHD, it 1 a complex neurodevelopmental disorder involving the abnormal functioning of multiple regions of the brain responsible for executive functions such as planning, decision-making, working memory, and behavioral inhibition. Neuroimaging studies have shown structural and functional differences in the brains of ADHD patients, for example, gray matter or white matter volume may be reduced in certain areas, and the regulation of neurotransmitters (especially dopamine and norepinephrine) may also be problematic. These neurobiological changes eventually lead to the typical symptoms of ADHD. In addition, studies have shown that the brain of ADHD patients may have a certain degree of chronic inflammation and oxidative stress.
Potential connection of Hbot adhd
Studies have shown (insert external link here: https://pmc.ncbi.nlm.nih.gov/articles/PMC8888529/) that HBOT has a certain effect in treating neuropsychological defects, so in what ways can adhd, which is also a related disorder of the nervous system, play a role?
Improves brain blood flow and oxygenation:
The brains of patients with ADHD, especially in areas related to executive function such as the prefrontal cortex, are sometimes found to have regional hypoperfusion or abnormal oxygen metabolism. Dysfunction in these areas directly affects attention, impulse control, and behavioral regulation.
By providing high concentrations of oxygen at high pressure, HBOT is able to significantly increase the dissolved oxygen in the plasma, thereby improving the oxygen supply to these areas, where the nerve cell function will be optimized, thereby potentially improving the core symptoms of ADHD.
Anti-inflammatory and antioxidant effects:
HBOT has been proven to have anti-inflammatory and antioxidant properties. It is capable of inhibiting the release of pro-inflammatory cytokines, reducing the inflammatory response, and activating the body’s own antioxidant enzyme system against the damage of free radicals. If some manifestations of ADHD are related to micro-inflammation or oxidative stress in the brain, it is possible that these properties of HBOT have a positive effect on symptoms by reducing inflammatory damage and protecting neurons.
Promotes neuroplasticity and repair:
HBOT can stimulate the expression of nerve growth factors and promote the growth, differentiation and formation of synaptic connections of neurons. In addition, it may help repair damaged nerve tissue and even stimulate the proliferation and differentiation of nerve stem cells.
For ADHD patients, hyperbaric chamber adhd may help reconstruct or optimize these key neural networks by enhancing neuroplasticity and repair mechanisms if there are tiny structural or functional connectivity abnormalities in the brain, thereby improving cognitive function and behavioral performance.
Regulates the neurotransmitter system:
One of the core pathophysiology of ADHD is related to imbalances in neurotransmitters such as dopamine and norepinephrine. Some theories speculate that HBOT may indirectly influence the synthesis, release, and reuptake of these key neurotransmitters by improving the brain environment and neuronal function.
Potential and risk of hyperbaric oxygen therapy adhd
potential
- Adjunctive to Existing Therapies: HBOT’s greatest potential lies in its potential as a powerful complement to existing treatments for ADHD. For patients who do not respond well to monotherapy or who wish to reduce their drug dose, HBOT can provide an additional dimension to improve their condition.
- Improving core symptoms: If the theoretical mechanism of action of HBOT is confirmed, it is expected to improve the core symptoms of ADHD.
- Improvement-related comorbidity: ADHD is often accompanied by other comorbidity, such as anxiety, depression, sleep disorders, etc. HBOT also shows some potential in improving brain function and emotion regulation, which can alleviate the comorbid distress of patients with ADHD, thereby improving the overall quality of life.
- Non-invasive: HBOT is the 1 relatively non-invasive treatment, and patients usually only need to breathe oxygen in a relaxed cabin.
risk
- Ear barotrauma: This is the most common side effect of HBOT. In a high pressure environment, an imbalance of pressure inside and outside the middle ear can cause pain, damage, and even perforation of the eardrum.
- Sinus pressure injury: Similar to ear barotrauma, sinuses can also be injured by pressure imbalance, causing pain or epistaxis.
- Vision changes: Some patients may experience temporary deepening of myopia after HBOT, which usually recovers after the course of treatment.
- Oxygen intoxication: Although rare, prolonged exposure to high concentrations of oxygen carries a risk of developing oxygen intoxication, which can lead to convulsions, lung damage, or central nervous system problems.
- Airtight phobia: The hyperbaric oxygen chamber is an airtight space, which can be a huge challenge for ADHD patients with airtight phobia or anxiety.
- Lack of ADHD-specific studies Despite the potential shown by HBOT in other neurological diseases, large-scale, high-quality, randomized controlled clinical studies on ADHD are still very limited. We still lack sufficient scientific evidence at present to clarify the effective dose, treatment regimen and long-term safety of HBOT for the treatment of ADHD.
- High costs and convenience: HBOT equipment is expensive to acquire and operate, treatment is relatively expensive, and not all regions have HBOT facilities, which limit the convenience of treatment. If long-term frequent treatment is determined to be necessary, either hyperbaric chamber rental or purchasing a hyperbaric chamber for home use may be considered.

Summary
The prevalence of ADHD and the limitations of traditional treatments have prompted us to look for new therapeutic directions. HBOT theoretically has a potential link with the pathophysiology of ADHD by improving brain oxygenation, anti-inflammation and promoting neural plasticity. However, this is still an area that requires in-depth study.
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